Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer.

Cell reports. Medicine - 20 Oct 2020

Essegian Derek, Khurana Rimpi, Stathias Vasileios, Schürer Stephan C

Abstract excerpt

The approval of the first kinase inhibitor, Gleevec, ushered in a paradigm shift for oncological treatment-the use of genomic data for targeted, efficacious therapies. Since then, over 48 additional small-molecule kinase inhibitors have been approved, solidifying the case for kinases as a highly druggable and attractive target class. Despite the role deregulated kinase activity plays in cancer, only 8% of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Discovery
Share to Gene Dosage
Share to Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Proteins

Share to Protein Kinases

Share to Research Design

Share to Small Molecule Libraries

Share to Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 33205077
DOI: 10.1016/j.xcrm.2020.100128
PMCID: PMC7659504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer.PMID 33205077Read ↗

The Clinical Kinase Index: Prioritizing Understudied Kinases as Targets for the Treatment of CancerSemantic proximity Read ↗

A resource for exploring the understudied human kinome for research and therapeutic opportunitiesSemantic proximity Read ↗

Polypharmacology is an enduring and nearly universal property of kinase inhibitorsSemantic proximity Read ↗

Analysis of Kinase Gene Expression Patterns across 5681 Human Tissue Samples Reveals Functional Genomic Taxonomy of the KinomeSemantic proximity Read ↗

Targeting the Human Kinome for Cancer Therapy: Current PerspectivesSemantic proximity Read ↗

The kinome 'at large' in cancer.Semantic proximity Read ↗

An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.Semantic proximity Read ↗

New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome.Semantic proximity Read ↗

Kinome-centric pharmacoproteomics identifies signaling pathways underlying cellular responses to targeted cancer drugsSemantic proximity Read ↗

Integrative kinomics reveals kinase-driven subtypes of gastric adenocarcinomas with sunitinib as a potential common inhibitorSemantic proximity Read ↗

Integrated Single-Dose Kinome Profiling Data is Predictive of Cancer Cell Line Sensitivity to Kinase InhibitorsSemantic proximity Read ↗

CMGC Kinases in Health and CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.