Article
STAT3 Signaling Heterogeneity Underlies Cytokine-Expressing Fate in Th17 Cultures.
ImmunoHorizons - 1 Nov 2023
Niese Michelle L, Glosson-Byers Nicole, Serezani Ana Paula Moreira, Alakhras Nada S, Kaplan Mark H
Abstract excerpt
The polarization of naive Th cells into differentiated subsets in vitro was a powerful approach to define the development and function of Th cells in vivo. Th cell cultures identified cytokines that promote polarization and defined the phenotype and stability of differentiated cells. One of the limitations of this approach is the heterogeneity of the differentiated culture, essentially with regard to what...
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