Article
Historical overview of the interleukin-6 family cytokine.
The Journal of experimental medicine - 4 May 2020
Kang Sujin, Narazaki Masashi, Metwally Hozaifa, Kishimoto Tadamitsu
Abstract excerpt
Interleukin-6 (IL-6) has been identified as a 26-kD secreted protein that stimulates B cells to produce antibodies. Later, IL-6 was revealed to have various functions that overlap with other IL-6 family cytokines and use the common IL-6 signal transducer gp130. IL-6 stimulates cells through multiple pathways, using both membrane and soluble IL-6 receptors. As indicated by the expanding market for IL-6 inhibitors,...
Topics
- Animals
- Genetic Pleiotropy
- History, 20th Century
- Humans
- Interleukin-6
- MicroRNAs
- Models, Biological
- Mutation
- Receptors, Interleukin-6