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Article

Evolutionary Changes of Hepatitis B Virus Pre-S Mutations Prior to Development of Hepatocellular Carcinoma.

PloS one - 1 Jan 2015

Zhang An-Ye, Lai Ching-Lung, Huang Fung-Yu, Seto Wai-Kay, Fung James, Wong Danny Ka-Ho, Yuen Man-Fung

Abstract excerpt

BACKGROUND AND AIMS: Deletions/mutations in the hepatitis B virus (HBV) pre-S region have been associated with hepatocellular carcinoma (HCC). We aimed to study the evolutionary changes of pre-S mutations prior to HCC development. METHODS: We studied the HBV pre-S sequences at 1 to 10 years preceding diagnosis of HCC in 74 patients with HBV-related HCC (HCC group). 148 chronic hepatitis B patients matched for sex...

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Identifiers

PMID: 26421619
DOI: 10.1371/journal.pone.0139478
PMCID: PMC4589234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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