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Article

Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses.

The Journal of experimental medicine - 7 Mar 2016

Lau Colleen M, Nish Simone A, Yogev Nir, Waisman Ari, Reiner Steven L, Reizis Boris

Abstract excerpt

A common genetic alteration in acute myeloid leukemia is the internal tandem duplication (ITD) in FLT3, the receptor for cytokine FLT3 ligand (FLT3L). Constitutively active FLT3-ITD promotes the expansion of transformed progenitors, but also has pleiotropic effects on hematopoiesis. We analyzed the effect of FLT3-ITD on dendritic cells (DCs), which express FLT3 and can be expanded by FLT3L administration....

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26903243
DOI: 10.1084/jem.20150642
PMCID: PMC4813676

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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