Article
Cutting edge: Flt3 ligand mediates STAT3-independent expansion but STAT3-dependent activation of myeloid-derived suppressor cells.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2014
Rosborough Brian R, Mathews Lisa R, Matta Benjamin M, Liu Quan, Raïch-Regué Dàlia, Thomson Angus W, Turnquist Hēth R
Abstract excerpt
The Flt3-Flt3 ligand (Flt3L) pathway is critically involved in the differentiation and homeostasis of myeloid cells, including dendritic cells (DC); however, its role in the expansion and function of myeloid-derived suppressor cells (MDSC) has not been determined. In this article, we describe the ability of Flt3L to expand and activate murine MDSC capable of suppressing allograft rejection upon adoptive transfer....
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