Article
FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.
Oncogene - 24 Nov 2005
Lee Benjamin H, Williams Ifor R, Anastasiadou Ema, Boulton Christina L, Joseph Sarah W, Amaral Sonia M, Curley David P, Duclos Nicole, Huntly Brian J P, Fabbro Doriano, Griffin James D, Gilliland Dwight Gary
Abstract excerpt
Activating FMS-like tyrosine kinase 3 (FLT3) mutations have been identified in approximately 30% of patients with acute myelogenous leukemia (AML), and recently in a smaller subset of patients with acute lymphoblastic leukemia (ALL). To explore the in vivo consequences of an activating FLT3 internal tandem duplication mutation (FLT3-ITD), we created a transgenic mouse model in which FLT3-ITD was expressed under...
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