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Article

Genetically Low Antioxidant Protection and Risk of Cardiovascular Disease and Heart Failure in Diabetic Subjects.

EBioMedicine - 1 Dec 2015

Kobylecki Camilla J, Afzal Shoaib, Nordestgaard Børge G

Abstract excerpt

BACKGROUND: Hyperglycemia-induced oxidative stress is one mechanism believed to underlie diabetic vascular disease. We tested the hypothesis that diabetic subjects heterozygous for extracellular superoxide dismutase (SOD3) R213G, which entails lower antioxidant capacity in tissues, have increased risk of cardiovascular disease and heart failure. METHODS: We used the prospective Copenhagen General Population Study...

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Identifiers

PMID: 26844281
DOI: 10.1016/j.ebiom.2015.11.026
PMCID: PMC4703764

Genes

SOD3

Variants

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