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Article

Association among extracellular superoxide dismutase genotype, plasma concentration, and comorbidity in the very old and centenarians.

Scientific reports - 20 Apr 2021

Sasaki Takashi, Abe Yukiko, Takayama Michiyo, Adachi Tetsuo, Okano Hideyuki, Hirose Nobuyoshi, Arai Yasumichi

Abstract excerpt

Superoxide dismutase 3 (SOD3), an antioxidant enzyme, is known as extracellular SOD (EC-SOD) because it is the predominant form in extracellular fluids. The diversity of plasma EC-SOD concentration is associated with the SOD3 p.R231G missense variant genotype. To clarify the association among SOD3 genotype, plasma EC-SOD concentration, and comorbidity in Oldest Old, we analyzed genome-wide associations with...

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Identifiers

PMID: 33879836
DOI: 10.1038/s41598-021-87982-6
PMCID: PMC8058336

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