Article
Genetically reduced antioxidative protection and increased ischemic heart disease risk: The Copenhagen City Heart Study.
Circulation - 6 Jan 2004
Juul Klaus, Tybjaerg-Hansen Anne, Marklund Stefan, Heegaard Niels H H, Steffensen Rolf, Sillesen Henrik, Jensen Gorm, Nordestgaard Børge G
Abstract excerpt
BACKGROUND: Extracellular superoxide dismutase (EC-SOD) is an antioxidative enzyme found in high concentrations in the arterial wall. Two to three percent of all people in Denmark carry an R213G substitution, which increases plasma concentration 10-fold. This may reduce arterial wall EC-SOD concentrations, increase intimal LDL oxidation, and therefore may accelerate atherogenesis. Our primary hypothesis was that...
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