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Article

Differential contribution for ERK1 and ERK2 kinases in BRAFV600E-triggered phenotypes in adult mouse models.

Cell death and differentiation - 1 Jun 2024

Bosso Giuseppe, Cintra Herpst Ana Carolina, Laguía Oscar, Adetchessi Sarah, Serrano Rosa, Blasco Maria A

Abstract excerpt

The BRAF gene is mutated in a plethora of human cancers. The majority of such molecular lesions result in the expression of a constitutively active BRAF variant (BRAFV600E) which continuously bolsters cell proliferation. Although we recently addressed the early effects triggered by BRAFV600E-activation, the specific contribution of ERK1 and ERK2 in BRAFV600E-driven responses in vivo has never been explored. Here...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38698060
DOI: 10.1038/s41418-024-01300-x
PMCID: PMC11165013

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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