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Article

Endoplasmic reticulum (ER) stress-induced reactive oxygen species (ROS) are detrimental for the fitness of a thioredoxin reductase mutant.

The Journal of biological chemistry - 3 Aug 2018

Kritsiligkou Paraskevi, Rand Jonathan D, Weids Alan J, Wang Ximeng, Kershaw Chris J, Grant Chris M

Abstract excerpt

The unfolded protein response (UPR) is constitutively active in yeast thioredoxin reductase mutants, suggesting a link between cytoplasmic thiol redox control and endoplasmic reticulum (ER) oxidative protein folding. The unique oxidative environment of the ER lumen requires tight regulatory control, and we show that the active UPR depends on the presence of oxidized thioredoxins rather than arising because of a...

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Identifiers

PMID: 29871930
DOI: 10.1074/jbc.RA118.001824
PMCID: PMC6078444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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