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Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes.

Free radical biology & medicine - 1 Jan 2000

Dardalhon Michèle, Kumar Chitranshu, Iraqui Ismail, Vernis Laurence, Kienda Guy, Banach-Latapy Agata, He Tiantian, Chanet Roland, Faye Gérard, Outten Caryn E, Huang Meng-Er

Abstract excerpt

Intracellular redox homeostasis is crucial for many cellular functions but accurate measurements of cellular compartment-specific redox states remain technically challenging. To better characterize redox control in the nucleus, we targeted a yellow fluorescent protein-based redox sensor (rxYFP) to the nucleus of the yeast Saccharomyces cerevisiae. Parallel analyses of the redox state of nucleus-rxYFP and...

Topics

Bacterial Proteins
Cell Compartmentation
Cell Nucleus
Cytosol
DNA, Fungal
Fluorescent Dyes
Glutathione
Hydrogen Peroxide
Luminescent Proteins
Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Oxidation-Reduction

Protein Transport

Saccharomyces cerevisiae

Thioredoxins

Source

Open in PubMed Open full text

Identifiers

PMID: 22561702
DOI: 10.1016/j.freeradbiomed.2012.04.004
PMCID: PMC3382975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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