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Article

Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes.

Molecular biology of the cell - 1 Apr 2002

Rodríguez-Manzaneque María Teresa, Tamarit Jordi, Bellí Gemma, Ros Joaquim, Herrero Enrique

Abstract excerpt

Yeast cells contain a family of three monothiol glutaredoxins: Grx3, 4, and 5. Absence of Grx5 leads to constitutive oxidative damage, exacerbating that caused by external oxidants. Phenotypic defects associated with the absence of Grx5 are suppressed by overexpression of SSQ1 and ISA2, two genes involved in the synthesis and assembly of iron/sulfur clusters into proteins. Grx5 localizes at the mitochondrial...

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Identifiers

PMID: 11950925
DOI: 10.1091/mbc.01-10-0517
PMCID: PMC102255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes.PMID 11950925Read ↗

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