Article
LGALS3 and AXIN1 gene variants playing role in the Wnt/ β-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer.
Bosnian journal of basic medical sciences - 4 Feb 2016
Korkmaz Gurbet, Horozoglu Cem, Arıkan Soykan, Gural Zeynep, Sağlam Esra Kaytan, Turan Saime, Özkan Nazlı Ezgi, Kahraman Ozlem Timirci, Yenilmez Ezgi Nurdan, Düzköylü Yigit, Doğan Mehmet Baki, Zeybek Umit, Ergen Arzu, Yaylım İlhan
Abstract excerpt
The Wnt pathway alterations have been identified in colorectal and many other cancer types. It has been reported that galectin-3 (which is encoded by the LGALS3 gene) alters the signaling mechanism in the Wnt/ β-catenin pathway by binding to β-catenin in colon and other cancers. AXIN1 is mainly responsible for the assembly of the β-catenin destruction complex in the Wnt pathway. This study investigated the...
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