Genetic Polymorphisms in APC, DVL2, and AXIN1 Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer.

doi:10.1620/tjem.249.173

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Article

Genetic Polymorphisms in APC, DVL2, and AXIN1 Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer.

The Tohoku journal of experimental medicine - 1 Nov 2019

Rosales-Reynoso Mónica Alejandra, Saucedo-Sariñana Anilú Margarita, Contreras-Díaz Karla Berenice, Márquez-González Rosa María, Barros-Núñez Patricio, Pineda-Razo Tomás Daniel, Marin-Contreras María Eugenia, Durán-Anguiano Óscar, Gallegos-Arreola Martha Patricia, Flores-Martínez Silvia Esperanza, Sánchez-Corona José

Abstract excerpt

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death worldwide. The named "destruction complex" has a critical function in the Wnt/β-catenin pathway regulating the level of β-catenin in the cytoplasm and nucleus. Alterations in this complex lead to the cellular accumulation of β-catenin, which participates in the development and progression of CRC. This study aims to...

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PMID: 31723073
DOI: 10.1620/tjem.249.173

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