Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Correction of fragile X syndrome in mice.

Neuron - 20 Dec 2007

Dölen Gül, Osterweil Emily, Rao B S Shankaranarayana, Smith Gordon B, Auerbach Benjamin D, Chattarji Sumantra, Bear Mark F

Abstract excerpt

Fragile X syndrome (FXS) is the most common form of heritable mental retardation and the leading identified cause of autism. FXS is caused by transcriptional silencing of the FMR1 gene that encodes the fragile X mental retardation protein (FMRP), but the pathogenesis of the disease is unknown. According to one proposal, many psychiatric and neurological symptoms of FXS result from unchecked activation of mGluR5,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acoustic Stimulation
Share to Fragile X Mental Retardation Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Functional Laterality

Share to Learning

Share to Neuronal Plasticity

Share to Receptor, Metabotropic Glutamate 5

Share to Receptors, Metabotropic Glutamate

Share to Visual Cortex

Source

Open in PubMed Open full text

Identifiers

PMID: 18093519
DOI: 10.1016/j.neuron.2007.12.001
PMCID: PMC2199268

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Correction of fragile X syndrome in mice.PMID 18093519Read ↗

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.Semantic proximity Read ↗

Investigating potential treatment strategies and underlying mechanisms in the Fragile X Syndrome mouse and rat modelsSemantic proximity Read ↗

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse.Semantic proximity Read ↗

Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome.Semantic proximity Read ↗

Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.Semantic proximity Read ↗

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.Semantic proximity Read ↗

New perspectives on the biology of fragile X syndrome.Semantic proximity Read ↗

Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium.Semantic proximity Read ↗

Advances in the treatment of fragile X syndrome.Semantic proximity Read ↗

Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome.Semantic proximity Read ↗

Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.Semantic proximity Read ↗

Fragile X syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.