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Article

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome.

Nature neuroscience - 22 Jan 2012

Ronesi Jennifer A, Collins Katie A, Hays Seth A, Tsai Nien-Pei, Guo Weirui, Birnbaum Shari G, Hu Jia-Hua, Worley Paul F, Gibson Jay R, Huber Kimberly M

Abstract excerpt

Enhanced metabotropic glutamate receptor subunit 5 (mGluR5) function is causally associated with the pathophysiology of fragile X syndrome, a leading inherited cause of intellectual disability and autism. Here we provide evidence that altered mGluR5-Homer scaffolds contribute to mGluR5 dysfunction and phenotypes in the fragile X syndrome mouse model, Fmr1 knockout (Fmr1(-/y)). In Fmr1(-/y) mice, mGluR5 was less...

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Identifiers

PMID: 22267161
DOI: 10.1038/nn.3033
PMCID: PMC3288402

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