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Article

Reduced axonal transport and increased excitotoxic retinal ganglion cell degeneration in mice transgenic for human mutant P301S tau.

PloS one - 1 Jan 2012

Bull Natalie D, Guidi Alessandra, Goedert Michel, Martin Keith R, Spillantini Maria Grazia

Abstract excerpt

The effects of tau hyperphosphorylation and aggregation on axonal transport were investigated in the optic nerve of mice transgenic for human mutant P301S tau. Transport was examined using cholera toxin B tracing. Retrograde transport was reduced in transgenic mice at 3 and 5 months of age, when...

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Identifiers

PMID: 22496848
DOI: 10.1371/journal.pone.0034724
PMCID: PMC3319610

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22496848-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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