Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

doi:10.1073/pnas.1521142113

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Article

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.

Proceedings of the National Academy of Sciences of the United States of America - 8 Mar 2016

Biagini Massimiliano, Spinsanti Marco, De Angelis Gabriella, Tomei Sara, Ferlenghi Ilaria, Scarselli Maria, Rigat Fabio, Messuti Nicola, Biolchi Alessia, Muzzi Alessandro, Anderloni Giulia, Brunelli Brunella, Cartocci Elena, Buricchi Francesca, Tani Chiara, Stella Maria, Moschioni Monica, Del Tordello Elena, Colaprico Annalisa, Savino Silvana, Giuliani Marzia M, Delany Isabel, Pizza Mariagrazia, Costantino Paolo, Norais Nathalie, Rappuoli Rino, Masignani Vega

Abstract excerpt

Factor H binding protein (fHbp) is a lipoprotein of Neisseria meningitidis important for the survival of the bacterium in human blood and a component of two recently licensed vaccines against serogroup B meningococcus (MenB). Based on 866 different amino acid sequences this protein is divided into three variants or two families. Quantification of the protein is done by immunoassays such as ELISA or FACS that are...

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Identifiers

PMID: 26888286
DOI: 10.1073/pnas.1521142113
PMCID: PMC4791009

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