Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.

doi:10.1128/IAI.00891-10

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.

Infection and immunity - 1 Feb 2011

Seib Kate L, Brunelli Brunella, Brogioni Barbara, Palumbo Emmanuelle, Bambini Stefania, Muzzi Alessandro, DiMarcello Federica, Marchi Sara, van der Ende Arie, Aricó Beatrice, Savino Silvana, Scarselli Maria, Comanducci Maurizio, Rappuoli Rino, Giuliani Marzia M, Pizza Mariagrazia

Abstract excerpt

Neisseria meningitidis is a commensal of the human nasopharynx but is also a major cause of septicemia and meningitis. The meningococcal factor H binding protein (fHbp) binds human factor H (fH), enabling downregulation of complement activation on the bacterial surface. fHbp is a component of two serogroup B meningococcal vaccines currently in clinical development. Here we characterize 12 fHbp subvariants for...

Topics

Amino Acid Sequence
Animals
Antibodies, Bacterial
Bacterial Proteins
Complement Factor H
Complement System Proteins
Female
Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Meningococcal Infections

Mice

Molecular Sequence Data

Neisseria meningitidis

Phylogeny

Protein Binding

Rabbits

Source

Open in PubMed Open full text

Identifiers

PMID: 21149595
DOI: 10.1128/IAI.00891-10
PMCID: PMC3028832

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.PMID 21149595Read ↗

Meningococcal factor H binding protein as immune evasion factor and vaccine antigenSemantic proximity Read ↗

Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal DiseaseSemantic proximity Read ↗

Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigenSemantic proximity Read ↗

Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccinesSemantic proximity Read ↗

Nonfunctional Variant 3 Factor H Binding Proteins as Meningococcal Vaccine CandidatesSemantic proximity Read ↗

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen MoleculesSemantic proximity Read ↗

The Meningococcal Vaccine Candidate Neisserial Surface Protein A (NspA) Binds to Factor H and Enhances Meningococcal Resistance to ComplementSemantic proximity Read ↗

Effect of factor H-binding protein sequence variation on factor H binding and survival of Neisseria meningitidis in human blood.Semantic proximity Read ↗

Distinct Binding and Immunogenic Properties of the Gonococcal Homologue of Meningococcal Factor H Binding ProteinSemantic proximity Read ↗

A region of the N-terminal domain of meningococcal factor H-binding protein that elicits bactericidal antibody across antigenic variant groups.Semantic proximity Read ↗

Expression of factor H binding protein in meningococcal strains can vary at least 15-fold and is genetically determined.Semantic proximity Read ↗

Factor H binding protein (FHbp): An evaluation of genotypic diversity across Neisseria meningitidis serogroups.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.