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Article

Diversity of factor H-binding protein in Neisseria meningitidis carriage isolates.

Vaccine - 11 Aug 2011

Marsh Jane W, Shutt Kathleen A, Pajon Rolando, Tulenko Mary M, Liu Stephen, Hollick Rosemary A, Kiehlbauch Julia A, Clark Thomas A, Stephens David S, Arnold Kathryn E, Myers Robert A, Mayer Leonard W, Harrison Lee H

Abstract excerpt

Several meningococcal vaccines under development for prevention of serogroup B disease target the factor H-binding protein (FHbp), an immunogenic lipoprotein expressed on the surface of Neisseria meningitidis. Based upon sequence and phylogenetic analyses, FHbp can be classified into 3 protein variants (1, 2 or 3) or 2 subfamilies (A or B). The potential effect of FHbp-containing vaccines on meningococcal...

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Identifiers

PMID: 21704667
DOI: 10.1016/j.vaccine.2011.06.025
PMCID: PMC4762365

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