Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen Molecules

25 Oct 2012

Abstract excerpt

Neisseria meningitis remains a leading cause of sepsis and meningitis, and vaccines are required to prevent infections by this important human pathogen. Factor H binding protein (fHbp) is a key antigen that elicits protective immunity against the meningococcus and recruits the host complement regulator, fH. As the high affinity interaction between fHbp and fH could impair immune responses, we sought to identify...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Infections and Vaccines
Share to Complement system in diseases
Share to Pneumonia and Respiratory Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23133374
DOI: 10.1371/journal.ppat.1002981

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Design and Evaluation of Meningococcal Vaccines through Structure-Based Modification of Host and Pathogen MoleculesPMID 23133374Read ↗

Nonfunctional Variant 3 Factor H Binding Proteins as Meningococcal Vaccine CandidatesSemantic proximity Read ↗

Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigenSemantic proximity Read ↗

Meningococcal factor H binding protein as immune evasion factor and vaccine antigenSemantic proximity Read ↗

Meningococcal Factor H Binding Protein Vaccine Antigens with Increased Thermal Stability and Decreased Binding of Human Factor H.Semantic proximity Read ↗

Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H.Semantic proximity Read ↗

Meningococcal factor H-binding protein: implications for disease susceptibility, virulence, and vaccinesSemantic proximity Read ↗

Distinct Binding and Immunogenic Properties of the Gonococcal Homologue of Meningococcal Factor H Binding ProteinSemantic proximity Read ↗

Rational design of a meningococcal antigen inducing broad protective immunity.Semantic proximity Read ↗

Role of Factor H Binding Protein in Neisseria meningitidis Virulence and Its Potential as a Vaccine Candidate To Broadly Protect against Meningococcal DiseaseSemantic proximity Read ↗

Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.Semantic proximity Read ↗

A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens.Semantic proximity Read ↗

Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.