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Article

The meningococcal vaccine candidate GNA1870 binds the complement regulatory protein factor H and enhances serum resistance.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2006

Madico Guillermo, Welsch Jo Anne, Lewis Lisa A, McNaughton Anne, Perlman David H, Costello Catherine E, Ngampasutadol Jutamas, Vogel Ulrich, Granoff Dan M, Ram Sanjay

Abstract excerpt

Neisseria meningitidis binds factor H (fH), a key regulator of the alternative complement pathway. A approximately 29 kD fH-binding protein expressed in the meningococcal outer membrane was identified by mass spectrometry as GNA1870, a lipoprotein currently under evaluation as a broad-spectrum meningococcal vaccine candidate. GNA1870 was confirmed as the fH ligand on intact bacteria by 1) abrogation of fH binding...

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Share to Adjuvants, Immunologic
Share to Binding Sites, Antibody

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blood Bactericidal Activity

Share to Complement Pathway, Alternative

Share to Meningococcal Vaccines

Share to Neisseria meningitidis

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Share to Vaccines, DNA

Source

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Identifiers

PMID: 16785547
DOI: 10.4049/jimmunol.177.1.501
PMCID: PMC2248442

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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