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Article

Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.

PLoS genetics - 1 Feb 2016

Zich Judith, May Karen, Paraskevopoulos Konstantinos, Sen Onur, Syred Heather M, van der Sar Sjaak, Patel Hitesh, Moresco James J, Sarkeshik Ali, Yates John R, Rappsilber Juri, Hardwick Kevin G

Abstract excerpt

The spindle checkpoint is a mitotic surveillance system which ensures equal segregation of sister chromatids. It delays anaphase onset by inhibiting the action of the E3 ubiquitin ligase known as the anaphase promoting complex or cyclosome (APC/C). Mad3/BubR1 is a key component of the mitotic checkpoint complex (MCC) which binds and inhibits the APC/C early in mitosis. Mps1(Mph1) kinase is critical for checkpoint...

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Identifiers

PMID: 26882497
DOI: 10.1371/journal.pgen.1005834
PMCID: PMC4755545

Genes

APC
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mps1Mph1 Kinase Phosphorylates Mad3 to Inhibit Cdc20Slp1-APC/C and Maintain Spindle Checkpoint Arrests.PMID 26882497Read ↗

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