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Article

Mutations in epigenetic modifiers in acute myeloid leukemia and their clinical utility.

Expert review of hematology - 1 May 2016

Hou Hsin-An, Tien Hwei-Fang

Abstract excerpt

Recent studies have identified recurrent mutations in genes that encode proteins crucial in the epigenetic regulation of gene transcription in hematologic malignancies. Somatic mutations in epigenetic modifiers, including IDH1, IDH2, TET2, DNAMT3A, ASXL1, MLL and EZH2 are enriched in patients with acute myeloid leukemia (AML), especially those with intermediate-risk cytogenetics. Here we describe the...

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Share to Dioxygenases
Share to Epigenesis, Genetic
Share to Histones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isocitrate Dehydrogenase

Share to Leukemia, Myeloid, Acute

Share to Molecular Targeted Therapy

Share to Neoplasm, Residual

Share to Translocation, Genetic

Source

Identifiers

PMID: 26789100
DOI: 10.1586/17474086.2016.1144469

Genes

ASXL1
IDH1
IDH2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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