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Myeloid- and hepatocyte-specific deletion of group VIA calcium-independent phospholipase A2 leads to dichotomous opposing phenotypes during MCD diet-induced NASH.

Biochimica et biophysica acta. Molecular basis of disease - 1 Jan 2023

Jansakun Chutima, Chunglok Warangkana, Altamura Sandro, Muckenthaler Martina, Staffer Simone, Tuma-Kellner Sabine, Merle Uta, Chamulitrat Walee

Abstract excerpt

Polymorphisms of phospholipase A2VIA (iPLA2β or PLA2G6) are associated with body weights and blood C-reactive protein. The role of iPLA2β/PLA2G6 in non-alcoholic steatohepatitis (NASH) is still elusive because female iPla2β-null mice showed attenuated hepatic steatosis but exacerbated hepatic fibrosis after feeding with methionine- and choline-deficient diet (MCDD). Herein, female mice with myeloid- (MPla2g6-/-)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36334837
DOI: 10.1016/j.bbadis.2022.166590

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