Article
Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers ApoB-Containing Lipoproteins in Mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2025
Helsley Robert N, Zelows Mikala M, Noffsinger Victoria P, Anspach Garrett B, Dharanipragada Nikitha, Mead Anna E, Cobo Isidoro, Carter Abigail, Wu Qinglin, Shalaurova Irina, Saito Kai, Morganti Josh M, Gordon Scott M, Graf Gregory A
Abstract excerpt
BACKGROUND: Genome- and epigenome-wide association studies have associated variants and methylation status of CPT1a (carnitine palmitoyltransferase 1a) to reductions in VLDL (very low-density lipoprotein) cholesterol and triglyceride levels. The objective of this study was to determine the mechanisms by which CPT1a-dependent mitochondrial fatty acid oxidation influences hepatic and lipoprotein metabolism....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.