Article
Nuclear localization of translocation partners in differentiating B-cells.
Doklady. Biochemistry and biophysics - 1 Jan 2015
Sklyar I V, Pichugin A M, Razin S V, Vassetzky E S, Iarovaia O V
Abstract excerpt
We studied the nuclear localization and relative position in the nuclear space of malignant translocation partner genes c-Myc, CCND1, and IGH locus in naive and differentiating B cells. We have shown that, during B-cell maturation, c-Myc and IGH loci become closer to each other. In differentiating lymphocytes, those alleles of c-Myc and IGH that are in close spatial proximity to each other are closer to the...
Topics
- Active Transport, Cell Nucleus
- Alleles
- B-Lymphocytes
- Cell Differentiation
- Cell Nucleus
- Cyclin D1
- Genetic Loci
- Immunoglobulin Heavy Chains
- Proto-Oncogene Proteins c-myc