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Genetic variants in multisynthetase complex genes are associated with DNA damage levels in Chinese populations.

Mutation research - 1 Apr 2016

Liu Jia, Zhu Meng, Chen Weihong, Xie Kaipeng, Shen Wei, Yuan Jing, Cheng Yang, Geng Liguo, Wang Yuzhuo, Jin Guangfu, Dai Juncheng, Ma Hongxia, Du Jiangbo, Wang Meilin, Zhang Zhengdong, Hu Zhibin, Wu Tangchun, Shen Hongbing

Abstract excerpt

Aminoacyl-tRNA synthetases (ARSs) and ARS-interacting multi-functional proteins (AIMPs) form a multisynthetase complex (MSC) and play an important role in the process of DNA damage repair. We hypothesized that genetic variants in key ARSs and AIMPs might regulate the DNA damage response. Therefore, we systematically screened 23 potentially functional polymorphisms in MSC genes and evaluated the association...

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Identifiers

PMID: 26871430
DOI: 10.1016/j.mrfmmm.2016.01.006

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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