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Article

Genetic Variants in MTHFR Gene Predict ≥ 2 Radiation Pneumonitis in Esophageal Squamous Cell Carcinoma Patients Treated with Thoracic Radiotherapy.

PloS one - 1 Jan 2017

Zhang Yang, Li Zongjuan, Zhang Jian, Li Hongsheng, Qiao Yumei, Huang Chengsuo, Li Baosheng

Abstract excerpt

Reactive oxygen species (ROS), formed as an indirect production of radiotherapy (RT), could cause DNA damage of normal tissues. Meanwhile, our body possesses the ability to restore the damage by DNA repair pathways. The imbalance between the two systems could finally result in radiation injury. Therefore, in this prospective cohort study, we explored the association of genetic variants in ROS metabolism and DNA...

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Share to Aged, 80 and over
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Esophageal Neoplasms

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 28046029
DOI: 10.1371/journal.pone.0169147
PMCID: PMC5207662

Genes

MTHFR
GSTA1
GSTP1
SOD2

Provenance

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