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Potentially functional polymorphisms in aminoacyl-tRNA synthetases genes are associated with breast cancer risk in a Chinese population.

Molecular carcinogenesis - 1 Jul 2015

He Yisha, Gong Jianhang, Wang Yanru, Qin Zhenzhen, Jiang Yue, Ma Hongxia, Jin Guangfu, Chen Jiaping, Hu Zhibin, Guan Xiaoxiang, Shen Hongbing

Abstract excerpt

Aminoacyl-tRNA synthetases (ARSs) are responsible for cellular protein synthesis and cell viability involving in various process of tumorigenesis. We hypothesized that genetic variants in core ARSs genes may play an important role in the development of breast cancer. Thus, we conducted a case-control study including 1064 breast cancer cases and 1073 cancer-free controls to evaluate the associations of 28...

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PMID: 24510587
DOI: 10.1002/mc.22128

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