Article
Personal exposure to PM2.5, genetic variants and DNA damage: a multi-center population-based study in Chinese.
Toxicology letters - 15 Jun 2015
Chu Minjie, Sun Chongqi, Chen Weihong, Jin Guangfu, Gong Jianhang, Zhu Meng, Yuan Jing, Dai Juncheng, Wang Meilin, Pan Yun, Song Yuanchao, Ding Xiaojie, Guo Xuejiang, Du Mulong, Xia Yankai, Kan Haidong, Zhang Zhengdong, Hu Zhibin, Wu Tangchun, Shen Hongbing
Abstract excerpt
Exposure to particulate matter (e.g., PM2.5) may result in DNA damage, a major culprit in mutagenesis and environmental toxicity. DNA damage levels may vary among individuals simultaneously exposed to PM2.5, however, the genetic determinants are still unclear. To explore whether PM2.5 exposure and genetic variants contribute to the alteration in DNA damage, we recruited 328 subjects from three independent cohorts...
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