Article

Huntingtin loss-of-function contributes to transcriptional deregulation in Huntington’s disease

2024-05-20

Abstract excerpt

Huntington’s disease (HD) is a fatal neurodegenerative disorder that is caused by the expansion of CAG repeats in the HTT gene, which results in a long polyglutamine (polyQ) tract in the huntingtin protein (HTT). In this study, we searched for networks of deregulated RNAs that contribute to initial transcriptional changes in HD neuronal cells and HTT-deficient cells. We used RNA-seq (including small RNA sequenci...

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Literature Corpus work: 1114e995-31ab-58e9-be06-6ac72484a170
DOI: 10.1101/2024.05.20.594947

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