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Article

Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease.

Scandinavian journal of gastroenterology - 1 Jan 2016

Park Soo-Kyung, Hong Myunghee, Ye Byong Duk, Kim Kyung-Jo, Park Sang Hyoung, Yang Dong-Hoon, Hwang Sung-Wook, Kwak Min Seob, Lee Ho-Su, Song Kyuyoung, Yang Suk-Kyun

Abstract excerpt

BACKGROUND: The impact of genetic variation in the thiopurine S-methyltransferase (TPMT) gene on thiopurine-induced leukopenia has been well demonstrated. Although xanthine dehydrogenase (XDH) is the second major contributor to azathioprine breakdown, polymorphisms in XDH have rarely been studied in IBD patients. We aim to access association between XDH variants and thiopurine-induced leukopenia by gene-gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26863601
DOI: 10.3109/00365521.2015.1133698

Genes

XDH
SUCLA2
TPMT
NUDT15

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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