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Article

Colon Cancer Tumorigenesis Initiated by the H1047R Mutant PI3K.

PloS one - 1 Jan 2016

Yueh Alexander E, Payne Susan N, Leystra Alyssa A, Van De Hey Dana R, Foley Tyler M, Pasch Cheri A, Clipson Linda, Matkowskyj Kristina A, Deming Dustin A

Abstract excerpt

The phosphoinositide 3-kinase (PI3K) signaling pathway is critical for multiple important cellular functions, and is one of the most commonly altered pathways in human cancers. We previously developed a mouse model in which colon cancers were initiated by a dominant active PI3K p110-p85 fusion protein. In that model, well-differentiated mucinous adenocarcinomas developed within the colon and initiated through a...

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Identifiers

PMID: 26863299
DOI: 10.1371/journal.pone.0148730
PMCID: PMC4749659

Genes

CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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