Article
Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.
The Biochemical journal - 1 Mar 2014
Hare Lauren M, Phesse Toby J, Waring Paul M, Montgomery Karen G, Kinross Kathryn M, Mills Kevin, Roh Vincent, Heath Joan K, Ramsay Robert G, Ernst Matthias, Phillips Wayne A
Abstract excerpt
PIK3CA, the gene encoding the p110α catalytic subunit of PI3K (phosphoinositide 3-kinase), is mutated in approximately 20% of sporadic CRCs (colorectal cancers), but the role of these mutations in the pathogenesis of CRC remains unclear. In the present study we used a novel mouse model to investigate the role of the Pik3caH1047R mutation, the most common PIK3CA mutation in CRC, during the development and...
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