Article
An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.
The Journal of clinical investigation - 1 Feb 2012
Kinross Kathryn M, Montgomery Karen G, Kleinschmidt Margarete, Waring Paul, Ivetac Ivan, Tikoo Anjali, Saad Mirette, Hare Lauren, Roh Vincent, Mantamadiotis Theo, Sheppard Karen E, Ryland Georgina L, Campbell Ian G, Gorringe Kylie L, Christensen James G, Cullinane Carleen, Hicks Rodney J, Pearson Richard B, Johnstone Ricky W, McArthur Grant A, Phillips Wayne A
Abstract excerpt
Mutations in the gene encoding the p110α subunit of PI3K (PIK3CA) that result in enhanced PI3K activity are frequently observed in human cancers. To better understand the role of mutant PIK3CA in the initiation or progression of tumorigenesis, we generated mice in which a PIK3CA mutation commonly detected in human cancers (the H1047R mutation) could be conditionally knocked into the endogenous Pik3ca locus....
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