Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations

Abstract excerpt

Abstract Therapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the PIK3CA gene, resulting in a constitutively active form of PI3K, often occur in colorectal cancer, though the population of patients who would...

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