Article
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2010
Hung Kenneth E, Maricevich Marco A, Richard Larissa Georgeon, Chen Wei Y, Richardson Michael P, Kunin Alexandra, Bronson Roderick T, Mahmood Umar, Kucherlapati Raju
Abstract excerpt
Most genetically engineered mouse (GEM) models for colon cancer are based on tissuewide or germline gene modification, resulting in tumors predominantly of the small intestine. Several of these models involve modification of the adenomatous polyposis coli (Apc) gene and are excellent models for familial cancer predisposition syndromes. We have developed a stochastic somatic mutation model for sporadic colon...
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