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Article

Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.

Nature - 18 Feb 2016

Farin Henner F, Jordens Ingrid, Mosa Mohammed H, Basak Onur, Korving Jeroen, Tauriello Daniele V F, de Punder Karin, Angers Stephane, Peters Peter J, Maurice Madelon M, Clevers Hans

Abstract excerpt

Mammalian Wnt proteins are believed to act as short-range signals, yet have not been previously visualized in vivo. Self-renewal, proliferation and differentiation are coordinated along a putative Wnt gradient in the intestinal crypt. Wnt3 is produced specifically by Paneth cells. Here we have generated an epitope-tagged, functional Wnt3 knock-in allele. Wnt3 covers basolateral membranes of neighbouring stem...

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Identifiers

PMID: 26863187
DOI: 10.1038/nature16937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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