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Article

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

American journal of respiratory and critical care medicine - 15 Jul 2016

Jiang Zhiqiang, Lao Taotao, Qiu Weiliang, Polverino Francesca, Gupta Kushagra, Guo Feng, Mancini John D, Naing Zun Zar Chi, Cho Michael H, Castaldi Peter J, Sun Yang, Yu Jane, Laucho-Contreras Maria E, Kobzik Lester, Raby Benjamin A, Choi Augustine M K, Perrella Mark A, Owen Caroline A, Silverman Edwin K, Zhou Xiaobo

Abstract excerpt

RATIONALE: A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies. However, the mechanisms by which FAM13A contributes to COPD susceptibility are unknown. OBJECTIVES: To determine the biologic function of FAM13A in human COPD and murine COPD models and discover the molecular mechanism by which FAM13A influences...

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Identifiers

PMID: 26862784
DOI: 10.1164/rccm.201505-0999OC
PMCID: PMC5003213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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