Article
FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2018
Corvol Harriet, Rousselet Nathalie, Thompson Kristin E, Berdah Laura, Cottin Guillaume, Foussigniere Tobias, Longchampt Elisabeth, Fiette Laurence, Sage Edouard, Prunier Céline, Drumm Mitchell, Hodges Craig A, Boëlle Pierre-Yves, Guillot Loic
Abstract excerpt
BACKGROUND: Cystic fibrosis (CF) lung disease severity is highly variable and dependent on several factors including genetic modifiers. Family with sequence similarity 13 member A (FAM13A) has been previously associated with lung function in the general population as well as in several chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), we examined whether FAM13A is a modifier gene of CF...
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