Article

Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition

2019-11-20

Abstract excerpt

Pulmonary hypertension is a progressive lung disease with poor prognosis due to the consequent right heart ventricular failure. Pulmonary artery remodeling and dysfunction are culprits for pathologically increased pulmonary arterial pressure, but their underlying molecular mechanisms remain to be elucidated. Previous genome-wide association studies revealed a significant correlation between the genetic locus of fa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 15ef9930-aa3a-57ae-86ad-59c25ff810f2
DOI: 10.1101/850115

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transitionDOI 10.1101/850115Read

A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.Semantic proximity Read

Exploring the pathogenesis of pulmonary vascular diseaseSemantic proximity Read

Characterising ATP13A3 biological function and its role in pulmonary arterial hypertensionSemantic proximity Read

Role of Forkhead box F1 in the Pathobiology of Pulmonary Arterial HypertensionSemantic proximity Read

Comparative Analyses of Lung Transcriptomes in Patients with Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins and in Foxf1 Heterozygous Knockout MiceSemantic proximity Read

KLF6 in Pulmonary Hypertension: The Dual Role of Friend and FoeSemantic proximity Read

Updated perspective of EPAS1 and the role in pulmonary hypertensionSemantic proximity Read

FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition.Semantic proximity Read

A Combined Targeted and Whole Exome Sequencing Approach Identified Novel Candidate Genes Involved in Heritable Pulmonary Arterial HypertensionSemantic proximity Read

Novel hub genes associated with pulmonary artery remodeling in pulmonary hypertensionSemantic proximity Read

Bronchopulmonary dysplasia with pulmonary hypertension associates with semaphorin signaling loss and functionally decreased FOXF1 expressionSemantic proximity Read

EIF2AK4 mutations cause pulmonary veno-occlusive disease, a recessive form of pulmonary hypertension.Semantic proximity Read