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Article

Influence of FAM13A gene polymorphism and serum matrix metalloproteinases 9 and 12 on the phenotypes of chronic obstructive pulmonary disease.

BMC pulmonary medicine - 24 Jun 2026

Zhao Di, Zhang Jiajun, Zhang Jin

Abstract excerpt

PURPOSE: FAM13A as a susceptibility gene for chronic obstructive pulmonary disease(COPD).Many studies verified that FAM13A involved epithelial‒mesenchymal transition (EMT) via the TGF-β1 pathway, some accompanied by an increase in MMP levels. The present study aimed to explore the disease susceptibility of the FAM13A gene, with clinical phenotypes, and investigate the relationships between FAM13A SNP loci and the...

Read the complete abstract on PubMed

Topics

Humans
Pulmonary Disease, Chronic Obstructive
Male
Polymorphism, Single Nucleotide
Female
Matrix Metalloproteinase 12

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Phenotype

Aged

Matrix Metalloproteinase 9

Genetic Predisposition to Disease

Case-Control Studies

GTPase-Activating Proteins

Genotype

Logistic Models

Respiratory Function Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 42343340
DOI: 10.1186/s12890-026-04441-6
PMCID: PMC13551843

Genes

FAM13A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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