Article
Variants in FAM13A are associated with chronic obstructive pulmonary disease.
Nature genetics - 1 Mar 2010
Cho Michael H, Boutaoui Nadia, Klanderman Barbara J, Sylvia Jody S, Ziniti John P, Hersh Craig P, DeMeo Dawn L, Hunninghake Gary M, Litonjua Augusto A, Sparrow David, Lange Christoph, Won Sungho, Murphy James R, Beaty Terri H, Regan Elizabeth A, Make Barry J, Hokanson John E, Crapo James D, Kong Xiangyang, Anderson Wayne H, Tal-Singer Ruth, Lomas David A, Bakke Per, Gulsvik Amund, Pillai Sreekumar G, Silverman Edwin K
Abstract excerpt
We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167,...
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