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The mammalian sperm factor phospholipase C zeta is critical for early embryo division and pregnancy in humans and mice

26 Apr 2024

Abstract excerpt

STUDY QUESTION: Are sperm phospholipase C zeta (PLCζ) profiles linked to the quality of embryogenesis and pregnancy? SUMMARY ANSWER: Sperm PLCζ levels in both mouse and humans correlate with measures of ideal embryogenesis whereby minimal levels seem to be required to result in successful pregnancy. WHAT IS KNOWN ALREADY: While causative factors underlying male infertility are multivariable, cases are...

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PMID: 38670547
DOI: 10.1093/humrep/deae078

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