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Article

Smad4 Inactivation Promotes Malignancy and Drug Resistance of Colon Cancer

19 Jan 2011

Abstract excerpt

SMAD4 is localized to chromosome 18q21, a frequent site for loss of heterozygosity in advanced stage colon cancers. Although Smad4 is regarded as a signaling mediator of the TGFβ signaling pathway, its role as a major suppressor of colorectal cancer progression and the molecular events underlying this phenomenon remain elusive. Here, we describe the establishment and use of colon cancer cell line model systems to...

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PMID: 21245094
DOI: 10.1158/0008-5472.can-09-3269

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