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Article

SMAD4 gene mutation predicts poor prognosis in patients undergoing resection for colorectal liver metastases.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 May 2018

Mizuno Takashi, Cloyd Jordan M, Vicente Diego, Omichi Kiyohiko, Chun Yun Shin, Kopetz Scott E, Maru Dipen, Conrad Claudius, Tzeng Ching-Wei D, Wei Steven H, Aloia Thomas A, Vauthey Jean-Nicolas

Abstract excerpt

INTRODUCTION: Dorsophilia protein, mothers against decapentaplegic homolog 4 (SMAD4) is a key mediator in the transforming growth factor (TGF)-β signaling pathway and SMAD4 gene mutations are thought to play a critical role in colorectal cancer (CRC) progression. However, little is known about its influence on survival in patients undergoing resection for colorectal liver metastases (CLM). METHODS: Between 2005...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29551247
DOI: 10.1016/j.ejso.2018.02.247

Genes

SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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