Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A SMAD4 ‐modulated gene profile predicts disease‐free survival in stage II and III colorectal cancer

10 Jun 2021

Abstract excerpt

BACKGROUND: Colorectal cancer is the second-leading cause of cancer-related mortality in the United States and a leading cause of cancer-related mortality worldwide. Loss of SMAD4, a critical tumor suppressor and the central node of the transforming growth factor-beta superfamily, is associated with worse outcomes for colorectal cancer patients; however, it is unknown whether an RNA-based profile associated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Growth Hormone and Insulin-like Growth Factors
Share to Radiomics and Machine Learning in Medical Imaging
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34114372
DOI: 10.1002/cnr2.1423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A SMAD4 ‐modulated gene profile predicts disease‐free survival in stage II and III colorectal cancerPMID 34114372Read ↗

A SMAD4-modulated gene profile predicts disease-free survival in stage II and III colorectal cancerSemantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysis.Semantic proximity Read ↗

Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal cancer: a systematic review and meta-analysisSemantic proximity Read ↗

A novel prognostic model for colorectal cancer based on epithelial cell marker genes identified and validated by combining Single-Cell and Bulk RNA- SequencingSemantic proximity Read ↗

Correlation Between SMADs and Colorectal Cancer Expression, Prognosis, and Immune InfiltratesSemantic proximity Read ↗

High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosisSemantic proximity Read ↗

Uncovering Potential Therapeutic Targets in Colorectal Cancer by Deciphering Mutational Status and Expression of Druggable OncogenesSemantic proximity Read ↗

Potential regulation and prognostic model of colorectal cancer with extracellular matrix genesSemantic proximity Read ↗

Prognosis prediction of stage IV colorectal cancer patients by mRNA transcriptional profile.Semantic proximity Read ↗

A RAS-Independent Biomarker Panel to Reliably Predict Response to MEK Inhibition in Colorectal CancerSemantic proximity Read ↗

Transcriptome-Wide Analysis and Experimental Validation from FFPE Tissue Identifies Stage-Specific Gene Expression Profiles Differentiating Adenoma, Carcinoma In-Situ and Adenocarcinoma in Colorectal Cancer ProgressionSemantic proximity Read ↗

Colon cancer molecular subtypes identified by expression profiling and associatedto stroma, mucinous type and different clinical behaviorSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.